Successful preimplantation genetic diagnosis to avoid creating a child affected by a genetically-based disorder was reported in 1989. Since then PGD has been used to biopsy and analyze embryos created through in viuo fertilization to avoid transferring to the mother’s uterus an embryo affected by a mutation or chromosomal abnormality associated with serious illness. PGD to avoid serious and early-onset illness in the child-to-be is widely accepted. PGD prevents gestation of an affected embryo and reduces the chance that the parents (...) will be faced with a difficult decision of whether to terminate the pregnancy. More controversial have been PGD to select the sex of the child-to-be for “family balancing”, PGD for mere susceptibility to disease and for late-onset disorders such as Alzheimer diseas, and most controversially, PGD to create a donor child who is Human Leukocyte Antigen (HLA-matched with a preexisting sibling in need of stem cell transplant. (shrink)

Successful preimplantation genetic diagnosis to avoid creating a child affected by a genetically-based disorder was reported in 1989. Since then PGD has been used to biopsy and analyze embryos created through in viuo fertilization to avoid transferring to the mother’s uterus an embryo affected by a mutation or chromosomal abnormality associated with serious illness. PGD to avoid serious and early-onset illness in the child-to-be is widely accepted. PGD prevents gestation of an affected embryo and reduces the chance that the parents (...) will be faced with a difficult decision of whether to terminate the pregnancy. More controversial have been PGD to select the sex of the child-to-be for “family balancing”, PGD for mere susceptibility to disease and for late-onset disorders such as Alzheimer diseas, and most controversially, PGD to create a donor child who is Human Leukocyte Antigen (HLA-matched with a preexisting sibling in need of stem cell transplant. (shrink)

Successful preimplantation genetic diagnosis (PGD) to avoid creating a child affected by a genetically-based disorder was reported in 1989. Since then PGD has been used to biopsy and analyze embryos created through in viuo fertilization (IVF) to avoid transferring to the mother’s uterus an embryo affected by a mutation or chromosomal abnormality associated with serious illness. PGD to avoid serious and early-onset illness in the child-to-be is widely accepted. PGD prevents gestation of an affected embryo and reduces the chance that (...) the parents will be faced with a difficult decision of whether to terminate the pregnancy. More controversial have been PGD to select the sex of the child-to-be for “family balancing” (rather than to avoid a sex-linked disorder), PGD for mere susceptibility to disease and for late-onset disorders such as Alzheimer diseas, and most controversially, PGD to create a donor child who is Human Leukocyte Antigen (HLA-matched with a preexisting sibling in need of stem cell transplant. (shrink)

Understanding the evolutionary role of environmentally induced phenotypic variation (i.e., plasticity) is an important issue in developmental evolution. A major physiological response to environmental change is cellular stress, which is counteracted by generic stress reactions detoxifying the cell. A model, stress‐induced evolutionary innovation (SIEI), whereby ancestral stress reactions and their corresponding pathways can be transformed into novel structural components of body plans, such as new cell types, is described. Previous findings suggest that the cell differentiation cascade of a cell type (...) critical to pregnancy in humans, the decidual stromal cell, evolved from a cellular stress reaction. It is hypothesized that the stress reaction in these cells was elicited ancestrally via inflammation caused by embryo attachment. The present study proposes that SIEI is a distinct form of plasticity‐based evolutionary change leading to the origin of novel structures rather than adaptive transformation of pre‐existing characters. (shrink)

“A fine collection of essays exploring, and in many cases extending, Jim Buchanan’s many contributions and insights to economic, political, and social theory.”– Bruce Caldwell, Professor of Economics, Duke University, USA"The overwhelming impression the reader gets from this very fine collection is the extraordinary expanse of James Buchanan's work. Everyone interested in economics and related fields can profit mightily from this book."– Mario Rizzo, Professor of Economics, New York University, USA This book explores the academic contribution of James Buchanan, who (...) received the Nobel Prize for economics in 1986. Buchanan’s receipt of the Prize is noteworthy because he was a maverick within the economics profession. In contrast to the preponderance of economists, Buchanan made little use of mathematics and no use of econometrics, preferring to used logic and language to insert his ideas into the scholarly community. Moreover, his ideas extended the domain of economic inquiry along many paths that numerous economists subsequently pursued. Buchanan’s scholarship brought economics and political science together under the rubric of public choice. He was also was a prime figure in bringing economic theory into closer contact with moral and social philosophy.This volume includes essays distributed across the extensive domain of Buchanan’s scholarly contributions, reflecting the range of his scholarly interests. Chapters will examine Buchanan’s scholarly work on public finance, social insurance, public debt, public choice, economic methodology, constitutional political economy, law and economics, and ethics and social theory. The book also examines Buchanan in relation to other prominent economists, both from the distant past and the recent past. (shrink)

This essay introduces a collection of 49 essays that exemplify the breadth and the depth of James M. Buchanan’sBuchanan, James M. contributions to economics in the post-war period. Buchanan started his career in 1948 as someone who wanted to provide a different scholarly framework for a theory of public finance and managed to do so. What resulted was a scholarly output that was published in 20 volumes in 2002, to which he continued to add until his death. The essays in (...) this volume reflect the breadth and depth of Buchanan’s contributions to political economy and social philosophy. While these essays are written by people who admired and learned from Buchanan’s work, these are not essays in hagiography. They explore various questions and topics that interested Buchanan. A good number of these explorations have critical overtones, but most significantly they build upon lines of inquiry that animated Buchanan’s scholarly curiosity. (shrink)

It is nearly universally presumed that redistribution can be carried out effectively only at the national or even global level, because local redistribution will be negated through personal mobility: recipients will move to high-paying jurisdictions while taxpayers will move away from those jurisdictions. To avoid this situation requires redistribution to be concentrated at national and not at local levels. In contrast to this standard line of argument, we explore how redistribution might be carried out more effectively at local levels than (...) at the national level. To explain this reversal from standard analytical implications, we integrate three concepts that are not present in the standard analysis. These concepts are the Samaritan’s dilemma, co-production, and polycentricity. It is interaction among these three concepts that reverses the implications of the standard analysis of redistribution. (shrink)

Nicholas Vriend asked whether F.A. Hayek was an “ace,” and answered affirmatively. By “ace,” Vriend meant someone who worked with agent-based modeling. To be sure, Hayek could not have worked with agent-based models because that platform did not exist when Hayek was developing his ideas about the distribution and use of knowledge in society. All the same, Vriend explained convincingly that Hayek could have made good use of the agent-based platform had it been available in the 1930s. To similar effect, (...) we argue in this paper that James Buchanan could have made good use of agent-based modeling to carry forward his ideas about the value of taking an emergent approach to the explanation of economic processes. (shrink)

In this paper, the relationship between the e-value of a complex hypothesis, H, and those of its constituent elementary hypotheses, Hj, j = 1… k, is analyzed, in the independent setup. The e-value of a hypothesis H, ev, is a Bayesian epistemic, credibility or truth value defined under the Full Bayesian Significance Testing mathematical apparatus. The questions addressed concern the important issue of how the truth value of H, and the truth function of the corresponding FBST structure M, relate to (...) the truth values of its elementary constituents, Hj, and to the truth functions of their corresponding FBST structures Mj, respectively. (shrink)

This volume contains the proceedings of JELIA '92, les Journ es Europ ennes sur la Logique en Intelligence Artificielle, or the Third European Workshop on Logics in Artificial Intelligence. The volume contains 2 invited addresses and 21 selected papers covering such topics as: - Logical foundations of logic programming and knowledge-based systems, - Automated theorem proving, - Partial and dynamic logics, - Systems of nonmonotonic reasoning, - Temporal and epistemic logics, - Belief revision. One invited paper, by D. Vakarelov, is (...) on arrow logics, i.e., modal logics for representing graph information. The other, by L.M. Pereira,J.J. Alferes, and J.N. Apar cio, is on default theory for well founded semantics with explicit negation. (shrink)

The Birkhoff-Maltsev problem asks for a characterization of those lattices each of which is isomorphic to the lattice L(K) of all subquasivarieties for some quasivariety K of algebraic systems. The current status of this problem, which is still open, is discussed. Various unsolved questions that are related to the Birkhoff-Maltsev problem are also considered, including ones that stem from the theory of propositional logics.

Despite the growing debate about scholarly impact, an analysis of the onto-epistemic grammar underlying impact has remained absent. By taking a different analytical approach to examining impact, we interrogate the concept through the lens of decolonial thought. We offer an empathetic review of the impact scholarship and illuminate the limits of the modern imaginary that circumscribe critiques of impact in the literature, making visible the Eurocentric and provincial horizons of modern reason underlying these critiques and impact in general. Drawing on (...) Śūnyatā ontological perspective, we seek to articulate from modernity imaginary’s edges and suggest imagining and being otherwise. We argue that the question of scholarly impact is intimately structured by and connected to the modern subject’s desire for ontological security. (shrink)

We assume, in the first place, that two kinds of processes occur in nature: the strictly continuous and causal ones, which are governed by the Schrödinger equation and those implying discontinuities, which are ruled by probability laws. In the second place, we adopt a postulate ensuring the statistical sense of conservation laws. These hypotheses allow us to state a rule telling, in principle, in which situations and to which vectors the system's state can collapse, and which are the corresponding probabilities. (...) The way our proposed approach works is illustrated with some examples and with the analysis of the measurement problem. We obtain the exponential decay law. A comparison with other attempts to solve the measurement problem is performed. (shrink)

LetL(K) denote the lattice (ordered by inclusion) of quasivarieties contained in a quasivarietyK and letD 2 denote the variety of distributive (0, 1)-lattices with 2 additional nullary operations. In the present paperL(D 2) is described. As a consequence, ifM+N stands for the lattice join of the quasivarietiesM andN, then minimal quasivarietiesV 0,V 1, andV 2 are given each of which is generated by a 2-element algebra and such that the latticeL(V 0+V1), though infinite, still admits an easy and nice description (...) (see Figure 2) while the latticeL(V 0+V1+V2), because of its intricate inner structure, does not. In particular, it is shown thatL(V 0+V1+V2) contains as a sublattice the ideal lattice of a free lattice with free generators. Each of the quasivarietiesV 0,V 1, andV 2 is generated by a 2-element algebra inD 2. (shrink)

How ought Christians to approach moral problems? This is a question of method in moral theology. It is also a question of who is in authority to speak on matters of morality. In this essay, the moral methodology of Richard McCormick, S.J., one of the most powerful voices in contemporary Roman Catholic theology, is explored in depth. Attention is focused on its critical details, its development over time, and in particular McCormick's use of authorities in Roman Catholicism. It is argued (...) that his ethical theory is built around one central insight: that the human person in all its facets and dimensions is the criterion of the rightness and wrongness of human actions. (shrink)

This is a reply to Luckiesh's comments (see 18: 608) on Tinker's\nreview of Luckiesh and Moss' book, _Reading as a visual task_\n(see 17: 962). (PsycINFO Database Record (c) 2010 APA, all\nrights reserved).

This Festschrift is one of the best we have been offered during the last decade. German, French, Turkish, Italian, South African, and Austrian scholars have written 23 essays in honor of one of the foremost historians of philosophy in this century, H. Heimsoeth. Half of the book is devoted to Kantian-scholarship; especially impressive are: Guéroult's study on the structure of the second analogy of experience, Belaval's comparison between Kant and Leibniz, and the richly documented long investigation by G. Tonelli on (...) the presuppositions of Kant's table of judgments in the logic of the eighteenth century. The second part of the present volume is more heterogeneous than the first. One reads with genuine enthusiasm H. Fuhrmans' "The God-World relationship in Schelling's late philosophy." L. Landgrebe's article on the philosophical problem of the end of history is grounded in Kantian soil, but other essays are little connected to Heimsoeth's major interests. These essays include: E. Lichtenstein on the philosophical development of the concept of culture from Meister Eckhart to Hegel; F. Nicolin on the systematic situation of the history of pedagogy since Herbart and Schleiermacher; and H. Wagner's paper on Plato and the beginning of metaphysics as a science. The book concludes with a rich bibliography of Heimsoeth's publications since 1911.--M. J. V. (shrink)

The same research proposal was submitted to 24 district health authority (DHA) research ethics committees in different parts of the country. The objective was to obtain permission for a multi-centre research project. The study of neonatal care in different types of unit (regional, subregional and district), required that four health authorities were approached in each of six widely separated health regions in England. Data were collected and compared concerning aspects of processing, including application forms, information required, timing and decision-making. The (...) key finding was that ethics committees received and processed the applications variably, reflecting individual factors and local problems. To improve consensus and facilitate multicentre studies, standard forms and instructions are suggested and the establishment of a national committee or advisory group advocated. (shrink)